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Pharmacophore modeling, in silico screening, molecular docking and molecular dynamics approaches for potential alpha-delta bungarotoxin-4 inhibitors discovery

BACKGROUND: The alpha-delta bungartoxin-4 (α-δ-Bgt-4) is a potent neurotoxin produced by highly venomous snake species, Bungarus caeruleus, mainly targeting neuronal acetylcholine receptors (nAchRs) and producing adverse biological malfunctions leading to respiratory paralysis and mortality. Objecti...

詳細記述

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書誌詳細
出版年:Pharmacogn Mag
主要な著者: Kumar, R. Barani, Suresh, M. Xavier, Priya, B. Shanmuga
フォーマット: Artigo
言語:Inglês
出版事項: Medknow Publications & Media Pvt Ltd 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4461960/
https://ncbi.nlm.nih.gov/pubmed/26109766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/0973-1296.157670
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