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Potent bace-1 inhibitor design using pharmacophore modeling, in silico screening and molecular docking studies

BACKGROUND: Beta-site amyloid precursor protein cleaving enzyme (BACE-1) is a single-membrane protein belongs to the aspartyl protease class of catabolic enzymes. This enzyme involved in the processing of the amyloid precursor protein (APP). The cleavage of APP by BACE-1 is the rate-limiting step in...

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Main Authors: John, Shalini, Thangapandian, Sundarapandian, Sakkiah, Sugunadevi, Lee, Keun Woo
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044283/
https://ncbi.nlm.nih.gov/pubmed/21342558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-12-S1-S28
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