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Potent bace-1 inhibitor design using pharmacophore modeling, in silico screening and molecular docking studies
BACKGROUND: Beta-site amyloid precursor protein cleaving enzyme (BACE-1) is a single-membrane protein belongs to the aspartyl protease class of catabolic enzymes. This enzyme involved in the processing of the amyloid precursor protein (APP). The cleavage of APP by BACE-1 is the rate-limiting step in...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3044283/ https://ncbi.nlm.nih.gov/pubmed/21342558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-12-S1-S28 |
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