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A pharmacokinetic model of oral methylphenidate in the rat and effects on behavior

Most animal studies using methylphenidate (MP) do not administer it the same way it is administered clinically (orally), but rather by injection, resulting in an altered pharmacokinetic profile (i.e. quicker and higher peak concentrations). Here, we evaluated several oral-dosing regimens in rats, in...

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Bibliografske podrobnosti
izdano v:Pharmacol Biochem Behav
Main Authors: Thanos, Panayotis K., Robison, Lisa S., Steier, Jessica, Hwang, Yu Fen, Cooper, Thomas, Swanson, James M., Komatsu, David E., Hadjiargyrou, Michael, Volkow, Nora D.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4461871/
https://ncbi.nlm.nih.gov/pubmed/25641666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pbb.2015.01.005
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