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A multi-label approach to target prediction taking ligand promiscuity into account

BACKGROUND: According to Cobanoglu et al., it is now widely acknowledged that the single target paradigm (one protein/target, one disease, one drug) that has been the dominant premise in drug development in the recent past is untenable. More often than not, a drug-like compound (ligand) can be promi...

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Detalhes bibliográficos
Publicado no:J Cheminform
Main Authors: Afzal, Avid M, Mussa, Hamse Y, Turner, Richard E, Bender, Andreas, Glen, Robert C
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4461803/
https://ncbi.nlm.nih.gov/pubmed/26064191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13321-015-0071-9
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