Potent KCNQ2/3-Specific Channel Activator Suppresses In Vivo Epileptic Activity and Prevents the Development of Tinnitus

Voltage-gated Kv7 (KCNQ) channels are voltage-dependent potassium channels that are activated at resting membrane potentials and therefore provide a powerful brake on neuronal excitability. Genetic or experience-dependent reduction of KCNQ2/3 channel activity is linked with disorders that are charac...

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Vydáno v:J Neurosci
Hlavní autoři: Kalappa, Bopanna I., Soh, Heun, Duignan, Kevin M., Furuya, Takeru, Edwards, Scott, Tzingounis, Anastasios V., Tzounopoulos, Thanos
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4461688/
https://ncbi.nlm.nih.gov/pubmed/26063916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5176-14.2015
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