Blockade of Multidrug Resistance-Associated Proteins Aggravates Acute Pancreatitis and Blunts Atrial Natriuretic Factor’s Beneficial Effect in Rats: Role of MRP4 (ABCC4)

We previously reported that atrial natriuretic factor (ANF) stimulates secretin-evoked cAMP efflux through multidrug resistance-associated protein 4 (MRP4) in the exocrine pancreas. Here we sought to establish in vivo whether this mechanism was involved in acute pancreatitis onset in the rat. Rats p...

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Detalhes bibliográficos
Publicado no:Mol Med
Main Authors: Ventimiglia, María Silvia, Najenson, Ana Clara, Perazzo, Juan Carlos, Carozzo, Alejandro, Vatta, Marcelo S, Davio, Carlos A, Bianciotti, Liliana G
Formato: Artigo
Idioma:Inglês
Publicado em: ScholarOne 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4461582/
https://ncbi.nlm.nih.gov/pubmed/25569802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2014.00166
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