Multidrug Resistance Protein 4 (MRP4/ABCC4) Regulates cAMP Cellular Levels and Controls Human Leukemia Cell Proliferation and Differentiation

Increased intracellular cAMP concentration plays a well established role in leukemic cell maturation. We previously reported that U937 cells stimulated by H2 receptor agonists, despite a robust increase in cAMP, fail to mature because of rapid H2 receptor desensitization and phosphodiesterase (PDE)...

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Autores principales: Copsel, Sabrina, Garcia, Corina, Diez, Federico, Vermeulem, Monica, Baldi, Alberto, Bianciotti, Liliana G., Russel, Frans G. M., Shayo, Carina, Davio, Carlos
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Molecular Bases of Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044954/
https://ncbi.nlm.nih.gov/pubmed/21205825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.166868
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