Adaptive Mutations Producing Efficient Replication of Genotype 1a Hepatitis C Virus RNA in Normal Huh7 Cells

Despite recent successes in generating subgenomic RNA replicons derived from genotype 1b strains of hepatitis C virus (HCV) that replicate efficiently in cultured cells, it has proven difficult to generate efficiently replicating RNAs from any other genotype of HCV. This includes genotype 1a, even t...

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Hlavní autoři: Yi, MinKyung, Lemon, Stanley M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2004
Témata:
Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC446091/
https://ncbi.nlm.nih.gov/pubmed/15254163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.15.7904-7915.2004
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