Mutations that permit efficient replication of hepatitis C virus RNA in Huh-7 cells prevent productive replication in chimpanzees

The development of a subgenomic replicon derived from the hepatitis C virus (HCV) strain Con1 enabled the study of viral RNA replication in Huh-7 cells. The level of replication of replicons, as well as full-length Con1 genomes, increased significantly by a combination of two adaptive mutations in N...

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Detalhes bibliográficos
Main Authors: Bukh, Jens, Pietschmann, Thomas, Lohmann, Volker, Krieger, Nicole, Faulk, Kristina, Engle, Ronald E., Govindarajan, Sugantha, Shapiro, Max, St. Claire, Marisa, Bartenschlager, Ralf
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC137898/
https://ncbi.nlm.nih.gov/pubmed/12391335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.212532699
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