Functional Antagonism of Chemokine Receptor CCR1 Reduces Mortality in Acute Pneumovirus Infection In Vivo

We present an antiviral-immunomodulatory therapeutic strategy involving the chemokine receptor antagonist Met-RANTES, which yields significant survival in the setting of an otherwise fatal respiratory virus infection. In previous work, we demonstrated that infection with the natural rodent pathogen...

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Detalhes bibliográficos
Main Authors: Bonville, Cynthia A., Lau, Vincent K., DeLeon, Jordana M., Gao, Ji-Liang, Easton, Andrew J., Rosenberg, Helene F., Domachowske, Joseph B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC446089/
https://ncbi.nlm.nih.gov/pubmed/15254170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.15.7984-7989.2004
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