The critical role of membralin in postnatal motor neuron survival and disease

Hitherto, membralin has been a protein of unknown function. Here, we show that membralin mutant mice manifest a severe and early-onset motor neuron disease in an autosomal recessive manner, dying by postnatal day 5–6. Selective death of lower motor neurons, including those innervating the limbs, int...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Yang, Bo, Qu, Mingliang, Wang, Rengang, Chatterton, Jon E, Liu, Xiao-Bo, Zhu, Bing, Narisawa, Sonoko, Millan, Jose Luis, Nakanishi, Nobuki, Swoboda, Kathryn, Lipton, Stuart A, Zhang, Dongxian
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2015
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4460860/
https://ncbi.nlm.nih.gov/pubmed/25977983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.06500
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