Structural investigations of T854A mutation in EGFR and identification of novel inhibitors using structure activity relationships

BACKGROUND: The epidermal growth factor receptor (EGFR) is a member of the ErbB family that is involved in a number of processes responsible for cancer development and progression such as angiogenesis, apoptosis, cell proliferation and metastatic spread. Malfunction in activation of protein tyrosine...

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Veröffentlicht in:BMC Genomics
Hauptverfasser: Goyal, Sukriti, Jamal, Salma, Shanker, Asheesh, Grover, Abhinav
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4460657/
https://ncbi.nlm.nih.gov/pubmed/26041145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-16-S5-S8
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