Virus-induced translational arrest through 4EBP1/2-dependent decay of 5′-TOP mRNAs restricts viral infection

The mosquito-transmitted bunyavirus, Rift Valley fever virus (RVFV), is a highly successful pathogen for which there are no vaccines or therapeutics. Translational arrest is a common antiviral strategy used by hosts. In response, RVFV inhibits two well-known antiviral pathways that attenuate transla...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Hopkins, Kaycie C., Tartell, Michael A., Herrmann, Christin, Hackett, Brent A., Taschuk, Frances, Panda, Debasis, Menghani, Sanjay V., Sabin, Leah R., Cherry, Sara
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4460451/
https://ncbi.nlm.nih.gov/pubmed/26038567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1418805112
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