Yeast Assay Highlights the Intrinsic Genomic Instability of Human PML Intron 6 over Intron 3 and the Role of Replication Fork Proteins

Human acute promyelocytic leukemia (APL) is characterized by a specific balanced translocation t(15;17)(q22;q21) involving the PML and RARA genes. In both de novo and therapy-related APL, the most frequent PML breakpoints are located within intron 6, and less frequently in intron 3; the precise mech...

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Pubblicato in:PLoS One
Autori principali: Chanet, Roland, Kienda, Guy, Heneman-Masurel, Amélie, Vernis, Laurence, Cassinat, Bruno, Guardiola, Philippe, Fenaux, Pierre, Chomienne, Christine, Huang, Meng-Er
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4460018/
https://ncbi.nlm.nih.gov/pubmed/26053431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129222
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