Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways

Gene multiplications or point mutations in alpha (α)-synuclein are associated with familial and sporadic Parkinson’s disease (PD). An increase in copper (Cu) levels has been reported in the cerebrospinal fluid and blood of PD patients, while occupational exposure to Cu has been suggested to augment...

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Detalhes bibliográficos
Publicado no:Neurobiol Dis
Main Authors: Anandhan, Annadurai, Rodriguez-Rocha, Humberto, Bohovych, Iryna, Griggs, Amy M., Zavala-Flores, Laura, Reyes-Reyes, Elsa M., Seravalli, Javier, Stanciu, Lia A., Lee, Jaekwon, Rochet, Jean-Christophe, Khalimonchuk, Oleh, Franco, Rodrigo
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4459946/
https://ncbi.nlm.nih.gov/pubmed/25497688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2014.11.018
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