Role of bacterial infection in the epigenetic regulation of Wnt antagonist WIF1 by PRC2 protein EZH2

The Enhancer of Zeste Homolog-2 (EZH2) represses gene transcription through histone H3 lysine-27-trimethylation (H3K27me3). Citrobacter rodentium (CR) promotes crypt hyperplasia and tumorigenesis by aberrantly regulating Wnt/β-catenin signaling. We aimed at investigating EZH2’s role in epigeneticall...

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Vydáno v:Oncogene
Hlavní autoři: Roy, Badal C., Subramaniam, Dharmalingam, Ahmed, Ishfaq, Jala, Venkatakrishna R., Hester, Christina, Greiner, K. Allen, Haribabu, Bodduluri, Anant, Shrikant, Umar, Shahid
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4459936/
https://ncbi.nlm.nih.gov/pubmed/25486432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.386
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