Pharmacological targeting of the protein synthesis mTOR/4E-BP1 pathway in cancer-associated fibroblasts abrogates pancreatic tumour chemoresistance

Pancreatic ductal adenocarcinoma (PDAC) is extremely stroma-rich. Cancer-associated fibroblasts (CAFs) secrete proteins that activate survival and promote chemoresistance of cancer cells. Our results demonstrate that CAF secretome-triggered chemoresistance is abolished upon inhibition of the protein...

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Bibliographic Details
Published in:EMBO Mol Med
Main Authors: Duluc, Camille, Moatassim-Billah, Siham, Chalabi-Dchar, Mounira, Perraud, Aurélie, Samain, Rémi, Breibach, Florence, Gayral, Marion, Cordelier, Pierre, Delisle, Marie-Bernadette, Bousquet-Dubouch, Marie-Pierre, Tomasini, Richard, Schmid, Herbert, Mathonnet, Muriel, Pyronnet, Stéphane, Martineau, Yvan, Bousquet, Corinne
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2015
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4459815/
https://ncbi.nlm.nih.gov/pubmed/25834145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201404346
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