mTOR Inhibition Suppresses Established Epilepsy in a Mouse Model of Cortical Dysplasia

OBJECTIVE: Hyperactivation of the mechanistic target of rapamycin (mTOR) pathway has been demonstrated in human cortical dysplasia (CD) as well as in animal models of epilepsy. While inhibition of mTOR signaling early in epileptogenesis suppressed epileptiform activity in the neuron subset-specific...

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Publicat a:Epilepsia
Autors principals: Nguyen, Lena H., Brewster, Amy L., Clark, Madeline E., Regnier-Golanov, Angelique, Sunnen, C. Nicole, Patil, Vinit V., D’Arcangelo, Gabriella, Anderson, Anne E.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4459784/
https://ncbi.nlm.nih.gov/pubmed/25752454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/epi.12946
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