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mTOR Inhibition Suppresses Established Epilepsy in a Mouse Model of Cortical Dysplasia
OBJECTIVE: Hyperactivation of the mechanistic target of rapamycin (mTOR) pathway has been demonstrated in human cortical dysplasia (CD) as well as in animal models of epilepsy. While inhibition of mTOR signaling early in epileptogenesis suppressed epileptiform activity in the neuron subset-specific...
Gorde:
| Argitaratua izan da: | Epilepsia |
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| Egile Nagusiak: | , , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2015
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4459784/ https://ncbi.nlm.nih.gov/pubmed/25752454 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/epi.12946 |
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