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Targeting neoplastic B cells and harnessing microenvironment: the “double face” of ibrutinib and idelalisib

Tyrosine kinase inhibitors (TKIs) targeting signaling molecules downstream B cell receptor (BCR) are powerfully spreading in the therapeutic landscape of B cell lymphoproliferative disease, due to a manageable toxicity profile and encouraging clinical effectiveness. In particular, ibrutinib, previou...

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Détails bibliographiques
Publié dans:J Hematol Oncol
Auteurs principaux: Maffei, Rossana, Fiorcari, Stefania, Martinelli, Silvia, Potenza, Leonardo, Luppi, Mario, Marasca, Roberto
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4459446/
https://ncbi.nlm.nih.gov/pubmed/26022368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-015-0157-x
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