Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity.

Familial amyotrophic lateral sclerosis (FALS) has been linked to mutations in the homodimeric enzyme Cu/Zn superoxide dismutase 1 (SOD1). Assay by transient expression in primate cells of six FALS mutant enzymes revealed a continuum of enzymatic activity bounded by the enzyme carrying the mutation G...

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Autores principales: Borchelt, D R, Lee, M K, Slunt, H S, Guarnieri, M, Xu, Z S, Wong, P C, Brown, R H, Price, D L, Sisodia, S S, Cleveland, D W
Formato: Artigo
Lenguaje:Inglês
Publicado: 1994
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC44592/
https://ncbi.nlm.nih.gov/pubmed/8058797
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