Excessive antigen reactivity may underlie the clinical aggressiveness of chronic lymphocytic leukemia stereotyped subset #8

Subset #8 is a distinctive subset of patients with chronic lymphocytic leukemia (CLL) defined by the expression of stereotyped IGHV4-39/IGKV1(D)-39 B-cell receptors. Subset #8 patients experience aggressive disease and exhibit the highest risk for Richter transformation among all CLL. In order to ob...

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Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Gounari, Maria, Ntoufa, Stavroula, Apollonio, Benedetta, Papakonstantinou, Nikos, Ponzoni, Maurilio, Chu, Charles C., Rossi, Davide, Gaidano, Gianluca, Chiorazzi, Nicholas, Stamatopoulos, Kostas, Ghia, Paolo
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2015
Soggetti:
Lymphoid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458798/
https://ncbi.nlm.nih.gov/pubmed/25900981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-09-603217
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