Primer ID Informs Next-Generation Sequencing Platforms and Reveals Preexisting Drug Resistance Mutations in the HIV-1 Reverse Transcriptase Coding Domain

Sequencing of a bulk polymerase chain reaction (PCR) product to identify drug resistance mutations informs antiretroviral therapy selection but has limited sensitivity for minority variants. Alternatively, deep sequencing is capable of detecting minority variants but is subject to sequencing errors...

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Bibliographic Details
Published in:AIDS Res Hum Retroviruses
Main Authors: Keys, Jessica R., Zhou, Shuntai, Anderson, Jeffrey A., Eron, Joseph J., Rackoff, Lauren A., Jabara, Cassandra, Swanstrom, Ronald
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc. 2015
Subjects:
Virology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458739/
https://ncbi.nlm.nih.gov/pubmed/25748056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2014.0031
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