Primer ID Informs Next-Generation Sequencing Platforms and Reveals Preexisting Drug Resistance Mutations in the HIV-1 Reverse Transcriptase Coding Domain

Sequencing of a bulk polymerase chain reaction (PCR) product to identify drug resistance mutations informs antiretroviral therapy selection but has limited sensitivity for minority variants. Alternatively, deep sequencing is capable of detecting minority variants but is subject to sequencing errors...

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Detalhes bibliográficos
Publicado no:AIDS Res Hum Retroviruses
Main Authors: Keys, Jessica R., Zhou, Shuntai, Anderson, Jeffrey A., Eron, Joseph J., Rackoff, Lauren A., Jabara, Cassandra, Swanstrom, Ronald
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2015
Assuntos:
Virology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458739/
https://ncbi.nlm.nih.gov/pubmed/25748056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2014.0031
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