Liver X Receptors Balance Lipid Stores in Hepatic Stellate Cells via Rab18, a Retinoid Responsive Lipid Droplet Protein

Liver X receptors (LXRs) are determinants of hepatic stellate cell (HSC) activation and liver fibrosis. Freshly isolated HSCs from Lxrαβ(−/−) mice have increased lipid droplet (LD) size but the functional consequences of this are unknown. Our aim was to determine whether LXRs link cholesterol to ret...

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Detalhes bibliográficos
Publicado no:Hepatology
Main Authors: O’Mahony, Fiona, Wroblewski, Kevin, O’Byrne, Sheila M., Jiang, Hongfeng, Clerkin, Kara, Benhammou, Jihane, Blaner, William S., Beaven, Simon W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458237/
https://ncbi.nlm.nih.gov/pubmed/25482505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.27645
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