Hepatic stellate cells retain retinoid-laden lipid droplets after cellular transdifferentiation into activated myofibroblasts

Loss of retinyl ester (RE)-rich lipid droplets (LDs) from hepatic stellate cells (HSCs) is cited as a key event in their cellular transdifferentiation to activated, pro-fibrotic myofibroblasts; however, it remains unclear if changes in LD morphology or RE content are causal for transdifferentiation....

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Udgivet i:Am J Physiol Gastrointest Liver Physiol
Main Authors: Jophlin, Loretta L., Koutalos, Yiannis, Chen, Chunhe, Shah, Vijay, Rockey, Don C.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6293250/
https://ncbi.nlm.nih.gov/pubmed/30024770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00251.2017
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