Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice

Liver fibrosis is a pathological condition in which chronic inflammation and changes to the extracellular matrix lead to alterations in hepatic tissue architecture and functional degradation of the liver. Inhibitors of the enzyme soluble epoxide hydrolase (sEH) reduce fibrosis in the heart, pancreas...

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Veröffentlicht in:Toxicol Appl Pharmacol
Hauptverfasser: Harris, Todd R., Bettaieb, Ahmed, Kodani, Sean, Dong, Hua, Myers, Richard, Chiamvimonvat, Nipavan, Haj, Fawaz G., Hammock, Bruce D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458210/
https://ncbi.nlm.nih.gov/pubmed/25827057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2015.03.022
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