All-Trans Retinoic Acid Activity in Acute Myeloid Leukemia: Role of Cytochrome P450 Enzyme Expression by the Microenvironment

Differentiation therapy with all-trans retinoic acid (atRA) has markedly improved outcome in acute promyelocytic leukemia (APL) but has had little clinical impact in other AML sub-types. Cell intrinsic mechanisms of resistance have been previously reported, yet the majority of AML blasts are sensiti...

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Pubblicato in:PLoS One
Autori principali: Su, Meng, Alonso, Salvador, Jones, Jace W., Yu, Jianshi, Kane, Maureen A., Jones, Richard J., Ghiaur, Gabriel
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457893/
https://ncbi.nlm.nih.gov/pubmed/26047326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0127790
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