Crystal Structure of USP7 Ubiquitin-like Domains with an ICP0 Peptide Reveals a Novel Mechanism Used by Viral and Cellular Proteins to Target USP7

Herpes simplex virus-1 immediate-early protein ICP0 activates viral genes during early stages of infection, affects cellular levels of multiple host proteins and is crucial for effective lytic infection. Being a RING-type E3 ligase prone to auto-ubiquitination, ICP0 relies on human deubiquitinating...

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Udgivet i:PLoS Pathog
Main Authors: Pfoh, Roland, Lacdao, Ira Kay, Georges, Anna A., Capar, Adam, Zheng, Hong, Frappier, Lori, Saridakis, Vivian
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457826/
https://ncbi.nlm.nih.gov/pubmed/26046769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004950
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