Acyl-CoA:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer’s disease mouse and reduces human P301L-tau content at the pre-symptomatic stage

Patients with Alzheimer’s disease (AD) display amyloidopathy and tauopathy. In mouse models of AD, pharmacological inhibition using small molecule enzyme inhibitors, or genetic inactivation of Acyl-CoA: cholesterol acyltransferase 1 (ACAT1) diminished amyloidopathy and restored cognitive deficits. I...

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Foilsithe in:Neurobiol Aging
Main Authors: Shibuya, Yohei, Niu, Zhaoyang, Bryleva, Elena Y., Harris, Brent T., Murphy, Stephanie R., Kheirollah, Alireza, Bowen, Zachary D., Chang, Catherine C.Y., Chang, Ta-Yuan
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2015
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457653/
https://ncbi.nlm.nih.gov/pubmed/25930235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2015.04.002
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