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Binding of imidazole, 1-methylimidazole and 4-nitroimidazole to yeast cytochrome c peroxidase (CcP) and the distal histidine mutant, CcP(H52L)

Imidazole, 1-methylimidazole and 4-nitroimidazole bind to yeast cytochrome c peroxidase (yCcP) with apparent equilibrium dissociation constants ([Formula: see text]) of 3.3 ± 0.4, 0.85 ± 0.11, and ~0.2 M, respectively, at pH 7. This is the weakest imidazole binding to a heme protein reported to date...

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Detalhes bibliográficos
Publicado no:Biochim Biophys Acta
Main Authors: Erman, James E., Chinchilla, Diana, Studer, Jason, Vitello, Lidia B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457651/
https://ncbi.nlm.nih.gov/pubmed/25907133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2015.04.013
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