Tight Chk1 Levels Control Replication Cluster Activation in Xenopus

DNA replication in higher eukaryotes initiates at thousands of origins according to a spatio-temporal program. The ATR/Chk1 dependent replication checkpoint inhibits the activation of later firing origins. In the Xenopus in vitro system initiations are not sequence dependent and 2-5 origins are grou...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Platel, Marie, Goldar, Arach, Wiggins, Jennifer M., Barbosa, Pedro, Libeau, Pierre, Priam, Pierre, Narassimprakash, Hemalatha, Grodzenski, Xenia, Marheineke, Kathrin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457610/
https://ncbi.nlm.nih.gov/pubmed/26046346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129090
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