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Tight Chk1 Levels Control Replication Cluster Activation in Xenopus
DNA replication in higher eukaryotes initiates at thousands of origins according to a spatio-temporal program. The ATR/Chk1 dependent replication checkpoint inhibits the activation of later firing origins. In the Xenopus in vitro system initiations are not sequence dependent and 2-5 origins are grou...
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| Izdano u: | PLoS One |
|---|---|
| Glavni autori: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Public Library of Science
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4457610/ https://ncbi.nlm.nih.gov/pubmed/26046346 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129090 |
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