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Genetic deficiency of the mitochondrial protein PGAM5 causes a Parkinson’s-like movement disorder

Mitophagy is a specialized form of autophagy that selectively disposes of dysfunctional mitochondria. Delineating the molecular regulation of mitophagy is of great importance because defects in this process lead to a variety of mitochondrial diseases. Here we report that mice deficient for the mitoc...

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Publicat a:Nat Commun
Autors principals: Lu, Wei, Karuppagounder, Senthilkumar S., Springer, Danielle A., Allen, Michele D., Zheng, Lixin, Chao, Brittany, Zhang, Yan, Dawson, Valina L., Dawson, Ted M., Lenardo, Michael
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457367/
https://ncbi.nlm.nih.gov/pubmed/25222142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5930
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