The lysyl oxidase inhibitor β-aminopropionitrile reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats

Extracellular matrix (ECM) remodelling of the adipose tissue plays a pivotal role in the pathophysiology of obesity. The lysyl oxidase (LOX) family of amine oxidases, including LOX and LOX-like (LOXL) isoenzymes, controls ECM maturation, and upregulation of LOX activity is essential in fibrosis; how...

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Dettagli Bibliografici
Pubblicato in:Dis Model Mech
Autori principali: Miana, María, Galán, María, Martínez-Martínez, Ernesto, Varona, Saray, Jurado-López, Raquel, Bausa-Miranda, Belén, Antequera, Alfonso, Luaces, María, Martínez-González, José, Rodríguez, Cristina, Cachofeiro, Victoria
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Company of Biologists 2015
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457038/
https://ncbi.nlm.nih.gov/pubmed/26035864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.020107
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