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Local triggering of the ICOS coreceptor by CD11c(+) myeloid cells drives organ inflammation in lupus
The inducible T cell costimulator (ICOS) is a potent promoter of organ inflammation in murine lupus. ICOS stimulates T follicular helper cell differentiation in lymphoid tissue, suggesting that it might drive autoimmunity by enhancing autoantibody production. Yet, the pathogenic relevance of this me...
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| Pubblicato in: | Immunity |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4456685/ https://ncbi.nlm.nih.gov/pubmed/25786178 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.02.015 |
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