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Local triggering of the ICOS coreceptor by CD11c(+) myeloid cells drives organ inflammation in lupus
The inducible T cell costimulator (ICOS) is a potent promoter of organ inflammation in murine lupus. ICOS stimulates T follicular helper cell differentiation in lymphoid tissue, suggesting that it might drive autoimmunity by enhancing autoantibody production. Yet, the pathogenic relevance of this me...
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Publicado no: | Immunity |
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Main Authors: | , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2015
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4456685/ https://ncbi.nlm.nih.gov/pubmed/25786178 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.02.015 |
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