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Local triggering of the ICOS coreceptor by CD11c(+) myeloid cells drives organ inflammation in lupus

The inducible T cell costimulator (ICOS) is a potent promoter of organ inflammation in murine lupus. ICOS stimulates T follicular helper cell differentiation in lymphoid tissue, suggesting that it might drive autoimmunity by enhancing autoantibody production. Yet, the pathogenic relevance of this me...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Teichmann, Lino L., Cullen, Jaime L., Kashgarian, Michael, Dong, Chen, Craft, Joe, Shlomchik, Mark J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456685/
https://ncbi.nlm.nih.gov/pubmed/25786178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.02.015
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