Validation of the Hsp70-Bag3 Protein-Protein Interaction as a Potential Therapeutic Target in Cancer

Heat shock protein 70 (Hsp70) is a stress-inducible molecular chaperone that is required for cancer development at several steps. Targeting the active site of Hsp70 has proven relatively challenging, driving interest in alternative approaches. Hsp70 collaborates with the Bcl2-associated athanogene 3...

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Veröffentlicht in:Mol Cancer Ther
Hauptverfasser: Li, Xiaokai, Colvin, Teresa, Rauch, Jennifer N., Acosta-Alvear, Diego, Kampmann, Martin, Dunyak, Bryan, Hann, Byron, Aftab, Blake T., Murnane, Megan, Cho, Min, Walter, Peter, Weissman, Jonathan S., Sherman, Michael Y., Gestwicki, Jason E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456214/
https://ncbi.nlm.nih.gov/pubmed/25564440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0650
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