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Computer-aided drug discovery approach finds calcium sensitizer of cardiac troponin

In the fight against heart failure, therapeutics that have the ability to increase the contractile power of the heart are urgently needed. One possible route of action to improve heart contractile power is increasing the calcium sensitivity of the thin filament. From a pharmaceutical standpoint, cal...

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Bibliographic Details
Published in:Chem Biol Drug Des
Main Authors: Lindert, Steffen, Li, Monica X., Sykes, Brian, McCammon, J. Andrew
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456024/
https://ncbi.nlm.nih.gov/pubmed/24954187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.12381
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