Translational regulation shapes the molecular landscape of complex disease phenotypes

The extent of translational control of gene expression in mammalian tissues remains largely unknown. Here we perform genome-wide RNA sequencing and ribosome profiling in heart and liver tissues to investigate strain-specific translational regulation in the spontaneously hypertensive rat (SHR/Ola). F...

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Vydáno v:Nat Commun
Hlavní autoři: Schafer, Sebastian, Adami, Eleonora, Heinig, Matthias, Rodrigues, Katharina E. Costa, Kreuchwig, Franziska, Silhavy, Jan, van Heesch, Sebastiaan, Simaite, Deimante, Rajewsky, Nikolaus, Cuppen, Edwin, Pravenec, Michal, Vingron, Martin, Cook, Stuart A., Hubner, Norbert
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Pub. Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4455061/
https://ncbi.nlm.nih.gov/pubmed/26007203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8200
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