LGR5 Activates Noncanonical Wnt Signaling and Inhibits Aldosterone Production in the Human Adrenal

CONTEXT: Aldosterone synthesis and cellularity in the human adrenal zona glomerulosa (ZG) is sparse and patchy, presumably due to salt excess. The frequency of somatic mutations causing aldosterone-producing adenomas (APAs) may be a consequence of protection from cell loss by constitutive aldosteron...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Clin Endocrinol Metab
Prif Awduron: Shaikh, Lalarukh Haris, Zhou, Junhua, Teo, Ada E. D., Garg, Sumedha, Neogi, Sudeshna Guha, Figg, Nichola, Yeo, Giles S., Yu, Haixiang, Maguire, Janet J., Zhao, Wanfeng, Bennett, Martin R., Azizan, Elena A. B., Davenport, Anthony P., McKenzie, Grahame, Brown, Morris J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Endocrine Society 2015
Pynciau:
Hot Topics in Translational Endocrinology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4454794/
https://ncbi.nlm.nih.gov/pubmed/25915569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2015-1734
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