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Molecular characterization of J558 genes encoding tight-skin mouse autoantibodies: identical heavy-chain variable genes code for antibodies with different specificities.

Tight-skin mouse, a mutant strain with a single gene defect, develops cutaneous hyperplasia and specific autoantibodies, like humans affected by scleroderma. The autoantibodies produced in the tight-skin mouse are encoded primarily by heavy-chain variable (VH) genes from the J558 family. To understa...

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Main Authors: Kasturi, K N, Yio, X Y, Bona, C A
格式: Artigo
語言:Inglês
出版: 1994
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC44546/
https://ncbi.nlm.nih.gov/pubmed/8058758
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