Whole Genome Sequencing Investigation of a Tuberculosis Outbreak in Port-au-Prince, Haiti Caused by a Strain with a “Low-Level” rpoB Mutation L511P – Insights into a Mechanism of Resistance Escalation

The World Health Organization recommends diagnosing Multidrug-Resistant Tuberculosis (MDR-TB) in high burden countries by detection of mutations in Rifampin (RIF) Resistance Determining Region of Mycobacterium tuberculosis rpoB gene with rapid molecular tests GeneXpert MTB/RIF and Hain MTBDRplus. Su...

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Pubblicato in:PLoS One
Autori principali: Ocheretina, Oksana, Shen, Lishuang, Escuyer, Vincent E., Mabou, Marie-Marcelle, Royal-Mardi, Gertrude, Collins, Sean E., Pape, Jean W., Fitzgerald, Daniel W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4454571/
https://ncbi.nlm.nih.gov/pubmed/26039194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129207
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