The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway

Loss of the mitochondrial protease activity of Omi causes mitochondrial dysfunction, neurodegeneration with parkinsonian features and premature death in mnd2 (motor neuron degeneration 2) mice. However, the detailed mechanisms underlying this pathology remain largely unknown. Here, we report that Om...

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Bibliografiska uppgifter
I publikationen:Cell Death Dis
Huvudupphovsmän: Xu, R, Hu, Q, Ma, Q, Liu, C, Wang, G
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2014
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4454303/
https://ncbi.nlm.nih.gov/pubmed/25118933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.328
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