Itraconazole solid dispersion prepared by a supercritical fluid technique: preparation, in vitro characterization, and bioavailability in beagle dogs

This research aimed to develop a supercritical fluid (SCF) technique for preparing a particulate form of itraconazole (ITZ) with good dissolution and bioavailability characteristics. The ITZ particulate solid dispersion was formulated with hydroxypropyl methylcellulose, Pluronic F-127, and L-ascorbi...

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Bibliographic Details
Published in:Drug Des Devel Ther
Main Authors: Yin, Xuezhi, Daintree, Linda Sharon, Ding, Sheng, Ledger, Daniel Mark, Wang, Bing, Zhao, Wenwen, Qi, Jianping, Wu, Wei
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2015
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4454206/
https://ncbi.nlm.nih.gov/pubmed/26060397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S81253
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