Heme oxygenase-1 protects against Alzheimer's amyloid-β(1-42)-induced toxicity via carbon monoxide production

Heme oxygenase-1 (HO-1), an inducible enzyme up-regulated in Alzheimer's disease, catabolises heme to biliverdin, Fe(2+) and carbon monoxide (CO). CO can protect neurones from oxidative stress-induced apoptosis by inhibiting Kv2.1 channels, which mediates cellular K(+) efflux as an early step i...

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Bibliographic Details
Published in:Cell Death Dis
Main Authors: Hettiarachchi, N, Dallas, M, Al-Owais, M, Griffiths, H, Hooper, N, Scragg, J, Boyle, J, Peers, C
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2014
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4454163/
https://ncbi.nlm.nih.gov/pubmed/25501830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.529
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