Severe Myelotoxicity Associated with Thiopurine S-Methyltransferase*3A/*3C Polymorphisms in a Patient with Pediatric Leukemia and the Effect of Steroid Therapy

Myelosuppression is a serious complication during treatment of acute lymphoblastic leukemia and the duration of myelosuppression is affected by underlying bone marrow failure syndromes and drug pharmacogenetics caused by genetic polymorphisms. Mutations in the thiopurine S-methyltransferase (TPMT) g...

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Veröffentlicht in:Turk J Haematol
Hauptverfasser: Belen, Burcu Fatma, Gürsel, Türkiz, Akyürek, Nalan, Albayrak, Meryem, Kaya, Zühre, Koçak, Ülker
Format: Artigo
Sprache:Inglês
Veröffentlicht: Galenos Publishing 2014
Schlagworte:
Case Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4454056/
https://ncbi.nlm.nih.gov/pubmed/25541649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4274/tjh.2013.0082
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