Identification and validation of dysregulated MAPK7 (ERK5) as a novel oncogenic target in squamous cell lung and esophageal carcinoma

BACKGROUND: MAPK7/ERK5 (extracellular-signal-regulated kinase 5) functions within a canonical three-tiered MAPK (mitogen activated protein kinase) signaling cascade comprising MEK (MAPK/ERK kinase) 5, MEKK(MEK kinase) 2/3 and ERK5 itself. Despite being the least well studied of the MAPK-modules, evi...

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Veröffentlicht in:BMC Cancer
Hauptverfasser: Gavine, Paul R., Wang, Mei, Yu, Dehua, Hu, Eva, Huang, Chunlei, Xia, Jenny, Su, Xinying, Fan, Joan, Zhang, Tianwei, Ye, Qingqing, Zheng, Li, Zhu, Guanshan, Qian, Ziliang, Luo, Qingquan, Hou, Ying Yong, Ji, Qunsheng
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453990/
https://ncbi.nlm.nih.gov/pubmed/26040563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1455-y
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