MRI reveals the in vivo cellular and vascular response to BEZ235 in ovarian cancer xenografts with different PI3-kinase pathway activity

BACKGROUND: The phosphoinositide-3 kinase (PI3K) pathway is an attractive therapeutic target. However, difficulty in predicting therapeutic response limits the clinical implementation of PI3K inhibitors. This study evaluates the utility of clinically relevant magnetic resonance imaging (MRI) biomark...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Cebulla, J, Huuse, E M, Pettersen, K, van der Veen, A, Kim, E, Andersen, S, Prestvik, W S, Bofin, A M, Pathak, A P, Bjørkøy, G, Bathen, T F, Moestue, S A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453650/
https://ncbi.nlm.nih.gov/pubmed/25535727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.628
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