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Histone deacetylase inhibitor SAHA epigenetically regulates miR-17-92 cluster and MCM7 to upregulate MICA expression in hepatoma

BACKGROUND: Epigenetic therapy using histone deacetylase inhibitors (HDACi) has shown promise in clinical trials for the treatment of human malignancies. In addition to the immediate effects on the tumour cell growth, HDACi upregulates the expression of MHC class I-related chain molecules A and B (M...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Yang, H, Lan, P, Hou, Z, Guan, Y, Zhang, J, Xu, W, Tian, Z, Zhang, C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453603/
https://ncbi.nlm.nih.gov/pubmed/25393367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.547
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